The oral calcium supplement for the prevention and treatment of milk fever
- Oral calcium salts are easy to administer.
- Clinical hypocalcaemia and loss of muscle function cause difficulties.
- Salts require administration into abomasum for proper absorption
- Two major risks in hypocalcaemia cow
- Administration into lungs (generally fatal)
- Rumenal deposition due to oesophogeal groove not working (loss of efficacy due to dilution of 180 litres of rumen fluid)
- Calol® is an oily emulsion of calcium chloride
- Thick nature
- Promotes swallow reflex
- Less likely to go into lungs
- Slows administration giving oesophogeal groove reflex a better chance to operate
- Oily nature
- Not diluted in aqueous medium of rumen
- Coats rumen wall like oil coats an engine
- Concentration gradient at mucosal junction
- Rumenal absorption
- Passive process
- Only calcium chloride is absorbed passively.
- Calcium chloride the only acidogenic calcium salt.
- Cl- ion absorbed more rapidly the Ca++.
- Electrostatic balance overrides acid/base.
- Hydrogen ions drawn through to lower blood pH.
- Lower pH stimulates bone mobilization.
- Ca++ in blood bound to protein.
- Only free Ca++ is active.
- Lower pH alters protein binding.
- Rapid increase of ionized calcium.
- Rapid response to treatment.
- Continued calcium absorption from gut.
- Mobilisation of bone calcium.
- Combine to keep levels elevated 12-14 hours.
- Total blood calcium includes free and bound calcium.
- Calol® has trial work in clinical cases of milk fever.
- Before calving to help prevent the occurrence of milk fever in susceptible cows.
- Following treatment with injectable calcium borogluconate or CalciTAD to reduce the possibility of relapse.
For prevention of Milk Fever
For cows that are especially prone to milk fever, Calol® may be used to prevent its incidence.
Prevention of milk fever can be achieved by drenching “at risk” cows with Calol® as follows;
Give 1 bottle of Calol® 24 hours before calving
Give 1 bottle of Calol® immediately after calving
Give 1 bottle of Calol® 10-12 hours after calving
Give 1 bottle of Calol® 20-24 hours after calving
To prevent relapse after treatment with calcium borogluconate or CalciTAD injection.
To supplement injectable treatment of milk fever and prevent relapse of the condition:
Give 1 bottle of Calol® as soon as the cow stands again.
Give 1 bottle of Calol® 10-14 hours later.
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NRA Approval No. 50275/0798
®Registered trademark of Cand. Pharm, Denmark.
Australian Patent No. 838.001
Calol® is registered in New Zealand under the Animal Remedies Act 1967, No. 7044. See www.foodsafety.govt.nz for registration conditions.