The oral calcium supplement for the prevention and treatment of milk fever

calol-bottle

•  Faster

•  Longer

•  Safer

Calol - Uniquely Effective
Calol Stage 1 - Better absorption
  • Oral calcium salts are easy to administer.
  • Clinical hypocalcaemia and loss of muscle function cause difficulties.
  • Salts require administration into abomasum for proper absorption
  • Two major risks in hypocalcaemia cow
    • Administration into lungs (generally fatal)
    • Rumenal deposition due to oesophogeal groove not working (loss of efficacy due to dilution of 180 litres of rumen fluid)
  • Calol® is an oily emulsion of calcium chloride
  • Thick nature
    • Promotes swallow reflex
    • Less likely to go into lungs
    • Slows administration giving oesophogeal groove reflex a better chance to operate
  • Oily nature
    • Not diluted in aqueous medium of rumen
    • Coats rumen wall like oil coats an engine
    • Concentration gradient at mucosal junction
  • Rumenal absorption
    • Passive process
    • Only calcium chloride is absorbed passively.
Calol Stage 2 - Faster Action
  • Calcium chloride the only acidogenic calcium salt.
  • Cl- ion absorbed more rapidly the Ca++.
  • Electrostatic balance overrides acid/base.
  • Hydrogen ions drawn through to lower blood pH.
  • Lower pH stimulates bone mobilization.
  • Ca++ in blood bound to protein.
  • Only free Ca++ is active.
  • Lower pH alters protein binding.
  • Rapid increase of ionized calcium.
  • Rapid response to treatment.
Calol Stage 3 - Longer Effect
  • Continued calcium absorption from gut.
  • Mobilisation of bone calcium.
  • Combine to keep levels elevated 12-14 hours.
  • Total blood calcium includes free and bound calcium.
  • Calol® has trial work in clinical cases of milk fever.
Molecular Size is the Difference
Calol® is a light yellow, creamy, water-in-oil emulsion containing 49.6g calcium as calcium chloride and 4.29g magnesium as magnesium chloride. Calol® contains soya oil and a palatable coconut and vanilla flavouring. Provided in ready-to drench bottles of 400ml, (packs of 4 bottles) or 5 litre multi-dose containers.
Calol® is an effective aid in the prevention and treatment of milk fever in cattle. Calol® may be given to cows;

  1. Before calving to help prevent the occurrence of milk fever in susceptible cows.
  2. Following treatment with injectable calcium borogluconate or CalciTAD to reduce the possibility of relapse.
The calcium chloride is rapidly absorbed following oral administration. Within 45 minutes significantly elevated blood calcium levels are achieved which are maintained for up to 14 hours. The magnesium content assists where mild hypomagnesaemia may coexist with hypocalcaemia. As well, Calol® helps lower blood pH which has the effect of significantly increasing the amount of free available calcium in the blood.
SHAKE WELL BEFORE USE

For prevention of Milk Fever

For cows that are especially prone to milk fever, Calol® may be used to prevent its incidence.

Prevention of milk fever can be achieved by drenching “at risk” cows with Calol® as follows;
Give 1 bottle of Calol® 24 hours before calving
Give 1 bottle of Calol® immediately after calving
Give 1 bottle of Calol® 10-12 hours after calving
Give 1 bottle of Calol® 20-24 hours after calving

To prevent relapse after treatment with calcium borogluconate or CalciTAD injection.

To supplement injectable treatment of milk fever and prevent relapse of the condition:
Give 1 bottle of Calol® as soon as the cow stands again.
Give 1 bottle of Calol® 10-14 hours later.

The water-in-oil emulsion of calcium chloride with soya oil greatly reduces the irritant effect that calcium chloride in solution or gel form can have on mucous membranes and the stomach lining. Calol®’s safety and efficacy has been well established with over 1 million bottles having been used in European dairy cows.
Avoid accidental administration into the trachea or lungs. Do not use in the absence of a swallowing reflex.
Blom, J.Y. National Committee on Cattle Husbandry Per, Comm., 1-89

Chieze, C. Rec. de Méd. Vét., 1992 168(5), 321-353

Daniel, R.C.W. Proc. N.Z. Soc. Anim. Prod., 1990, 160-165

Fürll, M. Proc. XiX World Buiatric Conr., 1996, 248-250

Glawisching, E. Proc. Int Meeting on Disease of Cattle, Wein 1992, 14 -15.

Goff, J.P. et al J.Dairy Sci., 1994 77(5), 1451-1456.

Hiess, G. Proc. 6th EAVPT Congr., 1994, 97-98

Hove, K. Irish Vet News, March 1987, 24-28

Kümper, H. Collegium Veterinarium XXIII, 1992, 19-32

Malling Olsen, P. Nord. Vet-Med, 1965, 17, 50-54

Massey, C.D. JAVMA, 1993, Vol. 203, (6), 852-853

Miljøministeriet Bekertgørelse nr. 69, 7. Feb 1996

Oetzel, G.R. Proc. Am. Dairy Sci. Meet., 1993, 304

Oetsel, G.R. J. Dairy Sci., 1991, 74 (11), 3900-3912

Philipsen, J.S. Dansk Vet Tidsskr., 1990, 73, 653-655

Pehrson, B. Dansk Vet Tidsskr., 1990, 73, 1207-1211

Ringarp, N. et al Zbl. Vet-Med., Reihe A, 1967, 14, 242-251

Simesen, M. G. Nord Vet-Med., 1971, 23, 35-43

Stein, M Top Agrar, 1992, 12, R24-25

Wentink, G. H. etal Vet. Quati, 1992, 14 (2), 76-79

Wermuth, N. C. Pers. Comm. on 19 January 1992

Wermuth, N. C. Proc. XVI World Buiatnic Congr, 1990, 525-531

NRA Approval No. 50275/0798
®Registered trademark of Cand. Pharm, Denmark.
Australian Patent No. 838.001

Calol® is registered in New Zealand under the Animal Remedies Act 1967, No. 7044. See www.foodsafety.govt.nz for registration conditions.

Calol proven safe in clinical milk fever cases