TriGene Advance

Distributed to the Medical/Healthcare sector by In Vitro

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Available as:

  • 100ml RTU spray
  • 500ml RTU spray
  • 1 Litre RTU Refill
  • 2 Litre RTU Refill
  • 20 Litre RTU Refill
  • Wipes 100’s
  • Wipes 200’s
  • 250ml concentrate
  • 1 Litre concentrate
  • 2 Litre concentrate
  • 5 Litre concentrate
  • 20 Litre concentrate
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Product Description

At the heart of the all-new TriGene Advance formula are the micro-emulsion particles (Nano particles) that enable the active ingredient molecules in the product to be carried rapidly through cell walls of micro-organisms.

Rapid penetration of cell walls by the powerful TriGene Advance disinfectant constituents ensures cell death is equally rapid. TriGene Advance works up to 70% quicker than conventional high level disinfectants and achieves apoptosis (cell death) rather than merely suspending activity as with conventional disinfectant products.

Because the Nano Particles can enter areas like microscopic fissures and crevices in hard surfaces, which have not hitherto been penetrable by conventional carrier systems, disinfectant actives are able to spread across a complete surface area, to perform a far more thorough anti pathogenic cleansing task than was previously possible.

The synergistic blend of TriGene Advance active ingredients produces the fastest acting and most efficient anti viral and sporicidal agent presently available in non-oxidising disinfectant technology.

Health and safety issues and product compatibility are of real importance to everyone. EA International encourages all users of chemical products to pay special attention to the advisory statements within Material Safety Data Sheets and on product labelling.

TriGene Advance is able to rely on lower levels of active ingredients than previously used, due to the formulation’s revolutionary method of delivering diluted disinfectant to the cells of micro-organisms. The simple prokaryotic cellular structure of micro-organisms provides little resistance to the active ingredients of TriGene Advance but the hugely more complex eukaryotic structure of the mammalian cell membrane means TriGene Advance is not cyto-toxic to mammalian tissue. Using the new system in the presence of human and animal skin is therefore of low risk. Notwithstanding this, instructions should always be followed carefully and gloves worn where advised.

Independent laboratory testing demonstrates no corrosion or deterioration of the following materials, even after long-term repeated immersions: Rubber compounds, Plastics, Fibreglass, Stainless Steel, Mild Steel, Aluminium, Copper, Brass and other materials found in clinical practice, in particular synthetic floors, instruments and devices.

Exposure controls

  • Skin contact: Low risk – may degrease skin leading to dryness if excessive contact.
  • Eye contact: Low risk – may cause temporary discomfort.
  • Inhalation: Low risk – avoid inhalation of fine mist spray.
  • Inhalation (long term): Low risk – avoid inhalation of fine mist spray.
  • Ingestion: Low risk – substantial ingestion will cause discomfort to mouth and digestive tissues.

Physical and chemical properties

  • pH: 5.5 (approx)

Toxicological information

  • Human Studies: 4 hour and 20 hours patch tests have shown minor skin reddening but no harmful effects.

Transport information

  • No special conditions apply. Not dangerous.

Accidental release measures

  • Environmental precautions: Product is biodegradable under OECD conditions operational 6/1995.
  • Clean up method: Flush to drain with copious water or soak up onto inert material.

Ecological information

  • No known adverse effects from normal use.
  • The TriGene Advance formula fully meets the criteria of the European Biocides Regulations which came into force in 2007.
  • TriGene Advance has not been tested on animals to secure its supporting data.

Because required results are generated with higher dilutions of TriGene Advance , greater economies are effected at point of use. For example, an acceptable ‘kill’ rate for Parvo virus is widely accepted as 99.99% (log 4) in a thirty minute exposure. This corresponds to the test protocol used by the UK Animal Health Institute and to the protocol accepted world-wide under EPA conditions.

TriGene Advance produces a 99.999+% (log 5+) kill rate in Parvo under the EPA protocol at a dilution of 1:100 (1 part disinfectant in 100 parts water).

Users of disinfectants in human health/laboratory and life science environments require maximum protection from the use of a disinfectant with proven independent microbiological test certification. Many disinfectants require strong dilutions for critical risk areas like Parvovirus or TB, yet are marketed for use at much weaker dilutions for “broad spectrum activity”, putting both the organisation and patients at risk of cross infection.

TriGene Advance users can rely on one dilution (1:100) for broad spectrum activity (supported by independent testing) in high risk conditions against viruses, mycobacteria, fungi and bacterial organisms and another for economic general purpose disinfection (1:200) in intermediate risk areas.

Worktops/equipment

  • Wash down all surfaces with TriGene Advance at 1:100 and dry with paper towel or allow to dry naturally. Alternatively use TriGene Advance in RTU (ready to use) trigger spray and wipe excess moisture with paper towel and allow to dry.
  • TriGene Advance wipes can also be used to wipe surfaces.

Device immersion

  • Non-critical devices can be soaked in TriGene Advance if required during a period of high risk in a solution of 1:100 for 20 mins.
  • Fabrics can be soaked in a solution of TriGene Advance at 1:100 for 10 minute. They can also be washed in an automatic washing machine using 50ml per 4kg load during a normal washing cycle.

Floor, walls

  • For general washing of floors and surfaces use TriGene Advance at 1:200. Use with mop and bucket on floors, remove excess moisture and allow to dry.
  • Wash other surfaces, rince where necessary and remove excess moisture and allow to dry.

Fogging and pressure washing

  • Where applicable TriGene Advance can be used in pressure washing machines at a dilution of 1:200, rinsed and allowed to dry.
  • Where aerial fogging is required, non-fragranced product should be used at a dilution of 1:200. masks should be worn and the area vacated until dry.

Wipes

  • TriGene Advance wipes, impregnated at 1:10 are recommended for disinfection of probes, transducers, incubators and for machines used for x-ray, mammography, radiology, etc.
  • As well as other sealed medical devices.
Methodology Organism Log Reduction Laboratory Dilution Clean/dirty conditions or low level soiling/high level soiling Time

Mycobactericidal

P2, S1 EN 14348

Mycobacterium avium

>2.79

Abbott Analytical

1:100

dirty

30 mins

Mycobacterium bovis

1.39

Abbott Analytical

1:100

dirty

30 mins

Mycobacterium fortuitum

<7.14

Abbott Analytical

1:100

dirty

30 mins

Mycobacterium terrae (TB)

>5.79

Abbott Analytical

1:100

dirty

30 mins

Virucidal

P2, S1 EN 14476

Canine parvovirus

5.67

Blutest

1:100

clean

30 mins

Adenovirus T5

4.16

Blutest

1:100

clean

30 mins

Feline Calicivirus

5.50

Blutest

1:100

clean

30 mins

U.S. EPA

Adenovirus T5

>5

ATS

1:100

5% FBS

30 mins

Hepatitis B

>4.21

ATS

1:100

N/A

30 mins

Human Immunodeficiency Virus T1

>4.5

ATS

1:100

5% FBS

30 mins

Human Coronavirus

>4.75

ATS

1:100

1% FBS

30 mins

Fungicidal / Yeasticidal

P2, S2 EN 13697

Candida albicans

>3.4

MGS

1:100

dirty

5 mins

P2, S1 EN 13624

Candida albicans

>5.06

MGS

1:100

clean

5 mins

Bactericidal

P2,S2 EN 14561

Enterococcus hirae

5.24

MGS

1:100

clean

5 mins

P2, S1 EN 1656

Enterococcus hirae

>5.08

MGS

1:200

low level soiling

5 mins

Staphylococcus aureus

>5.12

MGS

1:200

low level soiling

5 mins

Campylobacter jejuni

>5.36

MGS

1:200

low level soiling

5 mins

Stenotrophomonas maltophilia

>5.53

MGS

1:200

low level soiling

5 mins

Methicillin-resistant Staphylococcus pseudimintermedius

>5.44

MGS

1:200

low level soiling

5 mins

Proteus vulgaris

>5.16

MGS

1:200

low level soiling

5 mins

Streptococcus equi

>5.34

MGS

1:200

low level soiling

5 mins

Rhodococcus equi

5.40

MGS

1:100

low level soiling

5 mins

Bordatella bronchiseptica

4.15

MGS

1:100

low level soiling

5 mins

P2, S1 EN 13727

Methicillin-resistant Staphylococcus aureus

>5.34

MGS

1:200

clean

5 mins

Enterococcus hirae

>5.0

Eclipse

1:200

clean and dirty

5 mins

Staphylococcus aureus

>5.0

Eclipse

1:200

clean and dirty

5 mins

Pseudomonas aeruginosa

>5.0

Eclipse

1:200

clean and dirty

5 mins

P2, S1 EN 1276

Enterococcus hirae

>5.0

Eclipse

1:200

clean and dirty

5 mins

Staphylococcus aureus

>5.0

Eclipse

1:200

clean and dirty

5 mins

Pseudomonas aeruginosa

>5.0

Eclipse

1:200

clean and dirty

5 mins

Escherichia coli

>5.0

Eclipse

1:200

clean and dirty

5 mins

P2, S1 EN 1650

Microsporum audouinii

>4.3

University of Huddersfield

1:100

clean

30 mins

Trichophyton tonsurans

>4.1

University of Huddersfield

1:100

clean

60 mins